1,747 research outputs found
The diagnostic value of methylated DNA in laryngeal squamous cell carcinoma: meta-analysis
published_or_final_versio
The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis
published_or_final_versio
Direct writing of single germanium vacancy center arrays in diamond
© 2018 The Author(s). Color centers in diamond are promising solid-state qubits for scalable quantum photonics applications. Amongst many defects, those with inversion symmetry are of an interest due to their promising optical properties. In this work, we demonstrate a maskless implantation of an array of bright, single germanium vacancy (GeV) centers in diamond. Employing the direct focused ion beam technique, single GeV emitters are engineered with the spatial accuracy of tens of nanometers. The single GeV creation ratio reaches as high as 53% with the dose of 200 Ge + ions per spot. The presented fabrication method is promising for future nanofabrication of integrated photonic structures with GeV emitters as a leading platform for spin-spin interactions
MicroRNA 744-3p promotes MMP-9-mediated metastasis by simultaneously suppressing PDCD4 and PTEN in laryngeal squamous cell carcinoma
MicroRNA controls cancer invasion by governing the expression of gene regulating migration and invasion. Here, we reported a novel regulatory pathway controlled by miR-744-3p, which enhanced expression of matrix metallopeptidase 9 (MMP-9) in laryngeal squamous cell carcinoma (LSCC). We profiled the differential micoRNA expression pattern in LSCC cell lines and normal epithelial cultures derived from the head and neck mucosa using microRNA microarray. MiR-7-1-3p, miR-196a/b and miR-744-3p were expressed differentially in the LSCC cell lines. Subsequent validation using real-time PCR revealed that high miR-744-3p level was positively correlated with regional lymph node metastasis of LSCC. Real-time cellular kinetic analysis showed that suppressing miR-744-3p could inhibit migration and invasion of LSCC cell lines and reduce the number of lung metastatic nodules in nude mice modules. In silico analysis revealed that miR-744-3p targeted 2 distinct signaling cascades which eventually upregulated MMP-9 expression in LSCC. First, miR-744-3p could suppress programmed cell death 4 (PDCD4), a direct suppressor of NF-κB (p65). PDCD4 could also prevent AKT activation and suppress MMP-9 expression. Further, suppressing miR-744-3p expression could restore phosphatase and tensin homolog (PTEN) expression. PTEN could inhibit AKT activation and inhibit MMP-9 expression in LSCC cells. The results revealed that suppressing miR-744-3p was effective to inhibit LSCC metastasis by inactivating AKT/mTOR and NF-κB (p65) signaling cascade. Targeting miR-744-3p could be a valuable therapeutic intervention to suppress the aggressiveness of LSCC.published_or_final_versio
Optical Gating of Resonance Fluorescence from a Single Germanium Vacancy Color Center in Diamond
© 2019 American Physical Society. Scalable quantum photonic networks require coherent excitation of quantum emitters. However, many solid-state systems can undergo a transition to a dark shelving state that inhibits the resonance fluorescence. Here, we demonstrate that by a controlled gating using a weak nonresonant laser, the resonant fluorescence can be recovered and amplified for single germanium vacancies. Employing the gated resonance excitation, we achieve optically stable resonance fluorescence of germanium vacancy centers. Our results are pivotal for the deployment of diamond color centers as reliable building blocks for scalable solid-state quantum networks
An investigation of fast tool servo machining of optical microstructures
2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Ultra-precision machining technique for optical free-surface and its application
2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Ultra-precision machining of optical microstructures
2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Experimental measurement-based quantum computing beyond the cluster-state model
The paradigm of measurement-based quantum computation opens new experimental
avenues to realize a quantum computer and deepens our understanding of quantum
physics. Measurement-based quantum computation starts from a highly entangled
universal resource state. For years, clusters states have been the only known
universal resources. Surprisingly, a novel framework namely quantum computation
in correlation space has opened new routes to implement measurement-based
quantum computation based on quantum states possessing entanglement properties
different from cluster states. Here we report an experimental demonstration of
every building block of such a model. With a four-qubit and a six-qubit state
as distinct from cluster states, we have realized a universal set of
single-qubit rotations, two-qubit entangling gates and further Deutsch's
algorithm. Besides being of fundamental interest, our experiment proves
in-principle the feasibility of universal measurement-based quantum computation
without using cluster states, which represents a new approach towards the
realization of a quantum computer.Comment: 26 pages, final version, comments welcom
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